SYNTHESIS AND CHARACTERIZATION OF PYRIDYL BASED SCHIFF

Metal complexes are scientifically known to be active and effective as antibacterial, antivirus and some antifungal etc. This project work is targeted at preparing complex from transition metals say; cobalt, cupper, zinc and nickel and organic ligands synthesised from pyridyl based schiff bases, one from 2-aminopyridine and benzaldehyde and second from 2-aminopyridine and 2,4-dihydroxylbenzaldehyde. The analysis and completion is based on thin-layer chromatography, column-chromatography and IR-spectral analysis. 

TABLE OF CONTENTDedication…………………………………………………  iContent………………………………………………………iiAcknowledgement…………………………………………….iiiAbstract…………………………………………………………ivList of figures……………………………………………………vList of tables……………………………………………………..viList of equations…………………………………………………viiList of tables…………………………………………………..    viii
CHAPTER ONELITERATURE REVIEWIntroductionThe chemistry of transition elementsObjectives of study Complexes of transition elementswhy metal complexes are coluoredthe nature of chemical bonding in transition metal complexesEffect of the complex constituentsEffect of ligandsEffect of metal ionThe coordination chemistry of metal used (Nickel)The chemistry of Schiff Base (Imine)The Biological importance and activity of Schiff BaseLigand studiedPyridyl based Schiff Base           1.10. Apllications and activities of Schiff base complexes
CHAPTER TWO1.MATERIALS AND EQUIPMENT2.1. REAGENTS2.1.1. Ethanol2.1.2. Benz aldehyde2.1.3. 2, 4-dihydroxylbenzaldehyde2.1.4. Methanol2.1.5. Glacial acetic acid2.1.6. Diethyl ether2.1.7. n-hexane2.1.8. 2-aminopyridine2.1.9. Distilled Water 2.10. Dichloromethan2.11. Nickel metal salt2.12. Terpene oil2.13. Silica gel2.2.EQUIPMENT2.2.1. Reflux setup2.2.2. Distillation setup2.2.3. TLC plate and its materials2.2.4. UV machine2.2.5. Trituration setup2.2.6. Column chromatography setup2.2.7 Chemical Balance2.3. EXPERIMENTAL TECHNIQUES AND PROCEDURES2.3.1. General cleanupof glass wares and other apparatus2.3.2. Distillation of Benz aldehyde2.3.3. Refluxing to prepare our Schiff base in without catalyst2.3.4. Refluxing to prepare our Schiff base with catalyst 2.3.5. Concentration using rotary evaporator2.3.6. Running of TLC check2.3.7. Trituration of Schiff base produce from 2, 4-dihydroxyl benzaldehyde with diethylether and methanol in different setup2.3.8. Purification with column chromatography2.3.9. Refluxing of the Schiff base with the metal salt (copper nitrate)CHAPTER THREE3.1 RESULTS3.1.1. Melting point results3.1.2. FTIR results and analysisCHAPTER FOUR4.1 Discussion of result4.2 Conclusion 4.3. References.