Synthesis and Anti-Inflammatory Properties of Aminomethyl Derivatives of 2 Naphthol

ABSTRACT

The usefulness of non-steroidal anti-inflammatory agents in the management of rheumatoid diseases cannot be over-emphasized. As this disease is characterized by chronic inflammation, it is usual to test compounds for anti-inflammatory activity in animals and then hope that the active ones should be clinically useful as anti-rheumatic drugs, From the literature, non-steroidal anti-inflammatory agents have covered a wide range of chemical structures aryl acetic, aryl-propionic, arylbutyric and anthranilic ' acid derivatives, Other compounds including the benzothiazines are also known to be potent agents. This work involved the synthesis of some amino methyl derivatives of 2-naphthol and screening them as potential anti-inflammatory agents. These derivatives from the point of view of their electronic and stereochemical characteristics are considered to be similar to the known bis(2-hydroxynaphthy1)- methane derivatives, earlier L'G+UL led iu ilave pronounced anti-inflammatory activity, The physicochemical properties of these compounds were .also determined in an effort to correlate observed biological activity and chemical structure.