Structural Elucidation Of Compounds From Lonchocarpus Eriocalyx

Abstract

Preliminary validation of the extracts for bioactivity revealed that the n-hexane, DCM and MeOH extracts of the stem bark of L. eriocalyx were active against P. falciparum, A. gambie larvae, B. anthracis, and A. niger. This formed the the basis of fractionation of these crude extracts whereby lupeol (27), quercetin (65), apigenin (68) friedelin (133), -sitosterol (134), lupenone (135), -sitosterol-3-O-glucoside (136), chrysin (137) morinhydrate (138), quercetin-3-O-glucoside (139), 4’,5-dihydroxystilbene 3-O-glucoside (140) and rutin (141) were isolated. These compounds were obtained after successive silica gel column chromatography and their structures elucidated using physical and spectroscopic (NMR and MS) methods as well as comparison with literature data.