PROPHYLACTIC ACTIVITY OF Phyllantlms Amarus And Diodia Scandens IN SYNERGISM O SWI S ALBINO RATS

ABSTRACT

This study is aimed at evaluating the proP,hylactic activity of Phy/lanthus amarus and Diodia scandens in

synergism on the Swiss albino rats. The two plants were obtained from Federal University Oye-Ekiti and its

environs, thoroughly washed with distilled water and air dried at room temperature for two weeks. The air

dried plant materials were pulverized into powdery form using house-hold electric blender. Ethyl-acetate

extracts of the two plants combined was administered orally in the mouth of the Swiss albino rat as pretreatment

before challenging them with test organism (Coagulase Negative Staphylococcus). Results showed

that the concentration of combined extracts of the two plants at 25mg/kg and S0mg/kg were effective as a

prophylactic measures on the Swiss albino rats with no symptoms of diarrhoea, redness of the eyes and skin,

discharge from the eyes or death of the infected rat group. Conclusively, the synergistic effect of the two

plants combined had good antibacterial activities on Coagulase negative Staphylococci therefore the plants

can be administered in the treating related symptoms and other infectious disease caused by Coagulase negative Staphylococcus.