KIDNEY FUNCTION PARAMETERS F PLASMODIUM PASSAGED MICE TREATED WITH CRUDE METHANOLEXTRACT OF AZADIRACHTA INDICA (NEEM)

ABSTRACT

 Kidney function parameters were evaluated in plasmodium berghei infected mice treated with crude methanol extracts of Azadirachta indica leaves in this study. A total of  forty (40) male albino mice inoculated with quinine resistant strains of plasmodium berghei were randomized into nine (9) groups of (4) animals each while four additional mice serve as the uninfected control group. Group 1 was treated with tween 80, group 2 treated with 10mg/kg chloroquine while groups 3,4, and 5 were treated with 10mg/kg of chloroquine combined with 100,150 and 200mg/kg doses of crude extract Azadirachta indica. Groups 6, 7 and 8 were treated with graded doses of crude extract while groups 9 and 10 were treated with 1.14/6.85mg/kg artemether lumenfantrin and tween 80 respectively. All treatment began from day 3 and continued to day 5. Antimalarias activity was determined by taking blood smear from the tail on day 3 before treatment commences and on day 6 and 9. Results showed a dose dependent increase in chemosuppression and parasitaemia clearance by day 9 in the groups treated with CQ-extracts when compared to group 2 treated with CQ .There were significantly decrease in urea concentration (P>0.05) when compared with ALCTRL and CQCTRL. Creatinine concentration also decreased significantly (P