Invivo Assessment of The Embryotoxicity of Chloroquine in The Rat

ABSTRACT

The embryotoxicity potentials of normal dosage regimens of chloroquine used for therapeutic purposes were assessed in this research. Accordingly, five dosage regimens ^ . 5 ,10;0 12.5 15;0 and 20;0®g/kg body weight)=0f chtorocjuine diphosphate were screened by the High Performance Liquid Chromatography (HPLC) method to select those, which will provide whole blood levels: m the (Sprague-Dawley) rats comparable to those achievable during therapeutic use. The dosages of 7.5, 10,0 and 12.5 mg/kg body weight produced peak levels of 1,811,80 ng/ml (3.5 pM> lj688.34 ng/ml