Effect of Hibistycus sabdariffa Calyces Extract on Estrogen and Progesteron Level of Pregnant Albino Rats.

Abstract  This study investigated the effects of Hibiscus sabdariffa on the reproductive hormone of wistar rats.  Twenty eight wistar rats weighing between 160 – 200kg were used.  They were divided randomly into four groups (A – D) with seven animals in each of the groups.  Group A served as the control for group B and received 2ml of distilled water while group B orally received 2ml Hibiscus sabdariffa extract for 21 days, pregnancy was induced previously in these groups.  In the same vein, group C served as control for group D and orally received 2ml of Hibiscus sabdariffa extract for 21 days.  The results showed that there was significant increase in the level of estrogen in groups B and D compared to their control groups A and C.  Progesterone level in group B decreased significantly.  The mean body weight in group B animals increased significantly while animals in group C and D had no significant weight alteration.  It is concluded that administration of Hibiscus sabdariffa could cause an increased estrogen level in wistar rats.