Anti-Inflammatory Activity Of Aqueous Leaf Extract Of Brassica Oleraceae Linn Var.Dc (Brassicaceae)

ABSTRACT

The present study explored the anti-inflammatory potential of aqueous leaf extract of Brassica oleraceae in rodents, using standard laboratory models. Brassica oleraceae at doses of 75, 150 and 300 mg/kg were administered orally in carrageenan-induced rat hind paw edema, xylene induced ear edema in mice, and formalin-induced rat hind paw edema (sub-acute 7 days), using indomethacin (10 mg/kg), dexamethasone / mg/kg and acetylsalicylic acid (Aspirin, 100 mg/kg) respectively as standard drugs. The study further explored the effect of the extract on some inflammatory mediators, histamine, serotonin and prostaglandin, using only the highest dose of 300 mg/kg. The result obtained showed that aqueous extract of Brassica oleraceae produced a significant (p